I was just reading IPlural's handy shutdown shortcut tip, and I figured a thread full of such tips would be cool.
I don't know a whole lot, but one handy tip I can pass on is something that I came up with on my old system.
It was very slow, and at that time I had 2050 fonts installed, so it took ages for me to open my fonts folder to install new ones.
I found that if you create a shortcut to it in your 'send to' folder, you could then install fonts, both single and large groups, by simply right-clicking them and choosing that option.